Although other parameters can be used, SUVmax is the most widely accepted metric given its accuracy and simplicity of application in clinical practice 2, 5. The standardized uptake value (SUV) is a semiquantitative parameter used to measure tracer accumulation in tissues 2, 3. Radiolabeled deoxy-2-fluoro-D-glucose ( 18F-FDG), a glucose analogue, is the standard tracer used to evaluate neoplastic tissue 3, 4. Positron emission tomography/computed tomography (PET/CT) is an imaging modality used widely for diagnosis, staging, and therapeutic response assessment in oncology 1, 2. The lung was least affected by the variables in our model, and may serve as an alternative background tissue to the liver. In conclusion, the brain was the only organ analyzed showing a clinically significant relationship to glycemia after adjustment for potentially confounding variables. After adjustment for sex, age, and BMI, the association of glycemia with SUVmax was significant for the brain and liver, but not for the lung. No such difference was observed for the liver or lung. The brain was the only organ that presented a significant inverse relationship between SUVmax and glycemia (pā<ā0.001), even after controlling for diabetic status. Differences in mean SUVmax values among glycemic ranges were clinically significant only when >10% variation was observed. Patients were stratified into groups based on glucose levels, measured immediately before 18F-FDG injection. We retrospectively identified 5623 consecutive patients who had undergone clinical PET/CT for oncological indications. The influences of other confounding factors, such as body mass index (BMI), diabetes, age, and sex, on the relationships between glycemia and organ-specific standardized uptake values (SUVs) were also investigated. Our purpose was to evaluate the effect of glycemia on 18F-FDG uptake in normal organs of interest.
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